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(Special Tactical Anti-Gang) forces in Steelport, created by Senator Hughes to end gang violence once and for all. Her defection, however, coincides with the arrival of the paramilitary S.T.A.G. They are later joined by Viola DeWynter, one of Loren's twin lieutenants, after Killbane kills her twin sister Kiki out of rage due to a failed assassination attempt on the Boss. To retaliate, the Boss seeks out anti-Syndicate talent, recruiting Oleg as an enforcer, ex-FBI hacker Kinzie Kensington as an informant Zimos, the oldest pimp in Steelport and Angel de la Muerte, Killbane's vengeful former tag-team partner. The Boss briefly returns to Stilwater for Johnny Gat's funeral but while his hearse is held up at the reopening of the Hughes Memorial Bridge, overseen by Senator Monica Hughes, Killbane attacks the Saints and destroys the bridge. In this raid Loren is killed and the giant superhuman Oleg Kirlov, the basis of the cloned "brutes" the Syndicate uses, is rescued.
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The Boss quickly calls in another lieutenant from the Saints' hometown of Stilwater, Pierce Washington, and begins attacking the Morning Star's businesses, culminating with an attack on Loren's headquarters. Upon landing, the Boss and Shaundi find themselves in Steelport, the dystopian criminal city controlled by the Syndicate's three gangs: The Morning Star, a gang with advanced technology equipment, controlled by Loren himself, the Luchadores, a Mexican gang led by the killer wrestler Killbane, and the Deckers, a hacker-based gang led by Matt Miller. The Saints' leaders refuse and break out, but Gat is seemingly killed as the Boss and Shaundi escape via parachute. The Saints' leaders are shortly released to the man who owned the targeted bank, Phillipe Loren, the leader of a criminal organization known as "the Syndicate " on his private jet, Loren offers to let the Saints live if they turn over most of their earnings. The police, who they had paid off beforehand subsequently intervene and arrest the Saints.
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However, when the Saints' leader (usually referred to simply as "the Boss") and two lieutenants, Shaundi and Johnny Gat, attempt to rob a bank as a publicity stunt, the bank tellers unexpectedly start shooting back. Two years after the Ultor Corporation's destruction, the 3rd Street Saints have turned their street gang into a media empire, becoming icons and household names across the world, with their own energy drink, Japanese commercials, toys, a large fanbase, and a movie deal in the works.
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